Project Title Primary Supervisor Secondary Supervisor
3D modelling and haemodynamic analysis of patient specific abdominal aortic aneurysms Richard Bomphrey Yiannis Ventikos
3D Printing Bioengineered Muscle Professor Dominic Wells Dr Richard Day
A Genetic System to Study Clonal Interactions in the Brain Paulo Ribeiro Yanlan Mao
A Gut Reaction: The role of the gut microbiome in zebrafish neuronal development Dr Imelda McGonnell Albert Basson
A multidisciplinary approach to elucidate the central mechanisms driving pain after bone fracture Sandrine GERANTON Chantal Chenu, Professor of Skeletal Biology
A Multiplex Assembly Platform for Bioprinted Layer-By-Layer Mini-Tissues to study cell-cell interactions in 3D using High-Throughput live imaging techniques Dr. Simon Ameer-Beg Dr. Andrea Serio
A novel neuronal culturing system for patterned connectivity using 3D micro-needles Robert Hindges Ciro Chiappini
Acquiring a chemo-mechanical understanding of myosin dysregulation Julien Ochala Arianna Fornili
Actomyosin organisation in tissue repair and regeneration Yanlan Mao Shiladitya Banerjee
Advancing Muscle Regenerative Therapies via Phenotypic Analysis & Bioengineering Prof. Charles Knowles Dr Richard Day
An Effect of the LRRK2 kinase on Wnt signalling and bone architecture Professor Kirsten Harvey Andrew Pitsillides
Analysing the dynamics of gene regulatory adaptation in fission yeast Max Reuter Jürg Bähler
Analysis of the proteomic and transcriptomic landscape of nuclear degradation in epidermal keratinocytes Ryan O'Shaughnessy Kevin Mills
Bacterial subversion of innate immunity pathways: structural and cellular investigation of host-pathogen interactions in enteropathogenic E. coli infection Benjamin Stieglitz Dr. Olivier Marchès
Bayesian statistical inference of divergence times Mario dos Reis Ziheng Yang
Biomechanical analysis of cell migration in vivo Guillaume Charras Roberto Mayor
Blood brain barrier permeating platinum-peptide bioconjugates for the detection and destruction of brain tumours Kogularamanan Suntharalingam Rita Sousa-Nunes
Building better MiniBrains: Biomaterials directed generation of human brain organoids Dr Yung-Yao Lin Prof Alvaro Mata
Building stronger synapses: investigation of the structural role of CaMKII in long-term potentiation Matthew Gold Giulia Zanetti
Building the cilium with ATP-driven molecular motors Anthony Roberts Carolyn Moores
Cellular plasticity and heterogeneous modes of migration in development, health and disease Adrian Biddle Victoria Sanz Moreno
Chicken robots for social behaviour: From basic to applied research. Elisabetta Versace Siobhan Abeyesinghe
Co-translational protein folding and misfolding pathways observed by combined NMR and single-molecule force spectroscopy John Christodoulou Sergi Garcia-Manyes
Combining biophysical and synthetic chemistry to understand the mechanism of respiratory complex I Dr Maxie Roessler Dr Chris Jones
Combining structural, chemical and cellular biology to understand the role of capsid cofactor interactions in HIV innate immune evasion Gregory John Towers John Christodoulou
CompuBee: A computational model for integrative epigenetics analysis in the honeybee Dr Paul J. Hurd Dr Robert A. Lowe
Computing the biology of mitochondria in cell degeneration Michelangelo Campanella GyorgySzabadkai
Content-Aware AI Driven Super-Resolution Microscopy Ricardo Henriques Buzz Baum
Controlling and coordinating cell shape and size to generate a functional organ Buzz Baum Shiladitya Banerjee
CRISPR and cruzi: Deciphering the ICL DNA REPAIRtoire of Trypanosoma cruzi using genome editingCRISPR, cruzi and the DNA REPAIRtoire: Deciphering the ICL repair systems of Trypanosoma cruzi using genome editing Dr Shane Wilkinson Prof John Kelly
Deciphering operon variability and its regulation in mycobacteria using third-generation sequencing Dr Irilenia Nobeli Kristine Arnvig
Defining gene networks that control cell fate decision during vertebrate development Andrea Streit Chris Barnes
Defining the mechano-chemical signals controlling cancer cell invasion Professor Maddy Parsons Professor Guillaume Charras
Designing magnetic nanocapsules for combinatory cancer chemotherapy and photo-hyperthermia: combining chemistry with medicine Prof Khuloud K Al-Jamal Prof Nguyen TK Thanh
Designing Stable Structures of Leishmania major Small Hydrophilic Endoplasmic Reticulum associated Protein (SHERP): templates for Antibody Production and Rational Drug Design Doctor Robert William Janes Professor Bonnie Ann Wallace
Determination of the molecular mechanism of a cell fate decision and memory that declines during ageing. Fabrice Caudron Sasi Conte
Developing novel fibre-TIRF microscopy for understanding membrane protein turnover and dynamics. Guy Moss Philip Jones
Development of in vivo chemical cross-linking mass spectrometry approaches to study cell competition. Dr. Konstantinos Thalassinos Dr Alan R Lowe
Development of methods to improve structure resolution using EM data Prof Elena Orlova Pof Maya Topf
Dissecting the interplay between molecular and mechanical clues regulating cell migration and division Tania Maffucci John Connelly
Elucidating the mechanisms of action of dietary anthocyanins in women’s cardiovascular system by in silico, in vitro and in vivo studies Dr Ana Rodriguez-Mateos Prof. Carla Molteni
Enabling next-generation single-particle electron microscopy by delivering on ideally oriented antibody-fragment derivatized grids for optimal protein capture. Vijay Carolyn
Engineering 3D niches of liver tissues for regenerative medicine Shukry James Habib Eileen Gentleman
Engineering extracellular vesicles by nanoneedle-mediated endocytic modulation. Dr. Ciro Chiappini Professor Khuloud Al-Jamal
Engineering stable neural cell lines for nervous system regenerative medicine Dr James Phillips Prof Parmjit Jat
Evolution of neuropeptide signaling: finding the missing links Maurice Elphick Paola Oliveri
Evolutionary responses to meiotic drive Prof Andrew Pomiankowski Prof Kevin Fowler
Evolutionary rewiring of cellular energy metabolism Prof Snezhana Oliferenko Prof Jürg Bähler
Exploring the activation mechanisms of pentameric ligand gated ion channels by atomistic simulations and single channel methods Prof. Carla Molteni Prof. Lucia Sivilotti
Exploring Virulence strategies in Latent Tuberculosis: Structural and functional characterisation of Mammalian Cell entry (Mce) proteins. Vidya Darbari Dr. Viji Draviam
Face recognition and its variation across the visual field John Greenwood Dr. Tessa Dekker
Finite-element modelling of the inner ear and experimental characterization of its mechanical properties Torsten Marquardt Núria Gavara
Function and evolution of the Fam A protein family of malaria parasites in pathogenesis Christiaan van Ooij Nicholas Keep
Function of the Spectrin skeleton in regulating cell shape, cell mechanics, and epithelium architecture: a quantitative and biophysical investigation Isabel M Palacios Guillaume Charras
Functional and structural characterization of the pleiotropic transcriptional regulators SinR and CD2215 from Clostridium difficile Lisa Dawson Rivka Isaacson
Fundamentals of protein misfolding, Amyloid-beta (Aβ) assembly and Alzheimer’s disease John H. Viles Mark D. Baker
Genetics of Human Ageing – from populations to mechanisms Linda Partridge Karoline Kuchenbaecker
Growth and heredity of protocells at the origin of life under simulated hydrothermal conditions Professor Nick Lane Professor Andrew Pomiankowski
Haematopoietic stem cell exhaustion in ageing killifish Jurg Bahler Robert Knight
Harnessing the Melanocortin System (MCS) to moderate inflammation and enhance healthy ageing David Abraham Mauro Perretti
Host-microbiome interactions: Effects of microbiome modulation of vitamin D signalling on function and ageing of the nervous system Marina Ezcurra David Moyes
How CCAN contributes to chromosome segregation Lakxmi Subramanian Viji Draviam
How did past migrations, diet and environmental factors shape the genetic bases for cardiovascular and metabolic diseases in modern populations? Dr Anders Eriksson Dr Karoline Kuchenbaecker
How does my organ grow? Modelling mammalian growth in vivo. Marika Charalambous Robert Lowe
How the skeleton makes its shape: combining genetic and mathematical models Karen Liu Prof Karen Page
Identification and analysis of non-coding mRNA transcripts that regulate neurotrophin signalling in neurons Antonella Riccio Jernej Ule
Identification and metabolomic characterization of antimicrobial polyphenols from berry fruits Dr Daniele Castagnolo Dr Ana Rodriguez-Mateos
Imaging and selective stimulation of fascicles in the cervical vagus nerve using fast neural Electrical Impedance Tomography and new flexible penetrating electrodes Prof David Holder Mr Justin Perkins
Imaging Protein Glycosylation in Bacteria: A Chemical Biology Approach Gerd Wagner Professor Brendan Wren
Imaging the gut-brain axis: the role of microbial metabolites in blood-brain barrier permeability and interstitial solute clearance Andrea Malaspina Professor Mark Lythgoe
Improved understanding of the biological behaviour of anti-inflammatory lipid mediators through nano-scale liposomal delivery to the cell surface Dr Susan Anne BARKER Dr David BISHOP-BAILEY
Information processing in a neural circuit that links food to lifespan and ageing using automated microscopy in C. elegans QueeLim Ch'ng Chris Barnes
Innate immune signalling pathways in metabolic ageing Lazaros Foukas Pedro R. Cutillas
Integrity of the epidermal Autophagy pathway upon UV exposure and aging Dr Daniele Bergamaschi Dr Laurent Bozec
Interrogating protein sequence plasticity and function conservation at the outer limits of the twilight zone Renos Savva Mark Williams
Intra- and trans-generational memory in ageing Dr Nazif Alic Prof. Jürg Bähler
Investigating dog breed susceptibility to diabetes mellitus using stem cell-derived canine pancreatic beta cells Professor Lucy Davison Dr Jay Dudhia
Investigating how genome size interacts with nitrogen and phosphorus to impact crop productivity Andrew Leitch Professor Alexander Ruban
Investigating the cellular mechanisms of skeletal muscle regeneration using in vitro and experimental-data-driven computational modelling Ryo Torii Darren Player
Investigating the diseased extracellular matrix in keloid scars Brian Stramer Tanya Shaw
Investigating the intrinsic and extrinsic mechanisms of the expanding embryonic epithelium Masazumi Tada Ryo Torii
Investigating the relationship between metabolism, protein aggregation, and ageing using in vivo protein folding sensors and fluorescence lifetime imaging Michael Duchen Johnathan Labbadia
Investigating thymocyte migration and T-cell development using in vitro microfluidic model of human thymus microenvironment Dr Emad Moeendarbary Dr Paola Bonfanti
Label-free assessment of replicative senescence in flexor tendon fibroblasts Jay Dudhia Roger K Smith
Learning a data-driven model for diffusion MRI data using 3D microstructural imaging Helen Stolp J-Donald Tournier
Life expectancy beyond survival: exploring the requirements for sensory health, from flies …to mice ….to humans. Karen P Steel Joerg T Albert
Lysosomal protein function in the developing retina Claire Russell Anselm Zdebik
Mammalian and avian genomes: evolutionary earthquakes and stability Denis Larkin Judith Mank
Mechanistic basis for co-operativity in kinesin-1/cargo recognition Roberto Steiner Alessio Vagnoni
Mechanobiology of calvarial healing in mouse Dr. Mehran Moazen Dr. Karen Liu
Modelling human hypothalamic development in a dish Dr. Elena Bochukova Dr Robert Lowe
Modelling migraine headache “pain” using a microfluidic culture platform. Dr Ramin Raouf Professor Peter J. Goadsby
Modelling the impact of One Health interventions against foodborne toxoplasmosis Dr Martin Walker Professor Joanne Webster
Modifiers of lysosomal dysfunction Mario Falchi Claire Russell
Molecular and cellular characterization of neuroregeneration Paola Oliveri Geraint Thomas
Molecular characterisation of Candidalysin-epithelial membrane interactions Julian Naglik Stefan Howorka
Molecular mechanisms of AMPA receptor phosphorylation underlying synaptic plasticity Mark Farrant Matthew G. Gold
Monitoring CNS oxygenation and mitochondrial function during the development and resolution of a neuroinflammatory model of multiple sclerosis Kenneth Smith Ilias Tachtsidis
Multidisciplinary investigation of the role of sex hormone proteins in fibrotic lung disease Rivka Isaacson Joanna Porter
Neural mechanisms driving the decline of social cognition in healthy ageing: a computational modelling approach Clare Press Caroline Catmur
Neural mechanisms for dynamic modulation of protective reflexes Liam Browne Andrew Murray
Neural population coding underlying visually guided behaviour of larval zebrafish. Isaac Bianco Peter Latham
Neuronal Substrates of Perceptual Salience in the Auditory System Prof. Jennifer Linden Prof. Maneesh Sahani
Next generation sequencing of parasite field populations to explore population structure and genetic diversity Damer Blake Dong Xia
Next generation, immunocompetent 3D tissue models of cancer for testing targeted nanotechnology Marilena Loizidou David Abraham
Novel computational approaches to investigate agonistic and antagonistic interactions in brain functional networks in health and disease Dr Sagnik Bhattacharyya Dr Ginestra Bianconi
Novel mechanical and optogenetic technologies for investigating and controlling muscles involved in reaching and grasping in humans and mice Dr Lawrence Moon Dr Rui Loureiro
Novel Metabolite-based Tools for Pharmacodynamic Response Applications Professor Tony Ng Professor Helen Hailes
Novel Probes in Biology : Bifunctional rhodamines for in-situ protein orientation Dr Andre Cobb Dr Yin-Biao Sun
Parameterising a model for the emergence and spread of Viral Haemorrhagic Fevers (zoonoses) in West Africa Richard Kock Deborah Watson-Jones
Physical regulation of B cell activation using gold-templated antigen nanoarrays Katelyn Spillane Wayne Dickson
Polymersomes – can these unique nanoparticles be used to protect the heart? Derek Yellon Beppe Battaglia
Production and characterisation of disease-specific antibodies against infectious prions Dr Peter-Christian Kloehn Cleo Bishop
Production of antimicrobial materials using algal-derived peptides and enzymes Dr Lena Ciric Prof Saul Purton
Protein sorting and thylakoid membrane biogenesis in cyanobacteria: role of mRNA localisation Conrad Mullineaux Dr Christoph Engl
Quantitative analysis of prion structure and dynamics by TAB super-resolution microscopy Jan Bieschke Ricardo Henriques
Recent local adaptation in modern human populations. Aida Andres Garrett Hellenthal
Regulation of neural stem cell quiescence Rita Sousa-Nunes Jurg Bahler
Regulatory networks controlling persistent lamellipodial protrusion and cancer cell migration. Matthias Krause Attila Csikász-Nagy
Remodeling of redox cellular metabolic networks in response to mitochondrial dysfunction Gyorgy Szabadkai Alexandros Kiparissides
Resistance evolution in the presence of combination antibiotic therapy Gwen Knight Professor Tim McHugh
Resolving the role of the habenula in modulating social interactions. Stephen W.Wilson Elena Dreosti
Ribosomal RNA transcription in Trypanosoma brucei – decoding RNA polymerase-I regulation in an early diverging eukaryote Sam Alsford John Kelly
Ribosomes under attack – Single molecule analysis of bacterial translation in context of impaired rRNA stability and antimicrobial treatment. Dr Christoph Engl Dr Simon M. Ameer-Beg
Role of Endothelial to Mesenchymal Transition (EndoMT) in regulating vascular integrity and function Voon Ong Prof Caroline Wheeler-Jones
Role of mechanical stiffness on brain wound healing Roberto Mayor Guillaume Charras
Roles of the hippocampus in pain processing Andrew MacAskill Liam Browne
Sensory experience and pre-configured networks in developing neural circuits for navigation Francesca Cacucci Thomas Wills
Shedding light on the structure and regulation of yeast respiratory complex IV in isolation and in supercomplex using electron microscopy Amandine MARECHAL Giulia Zanetti
Single cell genomics of dynamical cell fate decisions Christopher Thompson Ruben Perez-Carrasco
Single molecule imaging of the dynamics of transcription factor binding in living cells Jonathan Chubb Karen Page
Smart lipid vesicles to understand cell membrane adhesion Salvador Tomas Emmanuel Boucrot
Sphingolipid Polar Heads: Hydrogen Bonding and Hydration Maria Eugenia Sanz Chris Lorenz
Structural studies of the gating mechanism in Type IV secretion system Shozeb Haider Vidya Darbari
Structure and mechanism of the conserved core of the SWI/SNF chromatin remodelling complex. Philip Robinson Dr Alan Lowe
Subversion of host pathways by the KSHV virus and the development of novel anti-virals Tracey Barrett Yasu Takeuchi
Super-resolution microscopy of functional synaptic vesicle pools Laura Andreae Susan Cox
Synaptosome on Chip (SyonChip): combining stem cell technologies, bioengineering and advanced molecular analysis to model the tripartite synapse in vitro Dr. Andrea Serio Dr. Rickie Patani
Synthesis of dynamic locomotor behaviours using deep learning applied to realistic musculoskeletal models of bipedal and quadrupedal animals Dr Monica A Daley Professor John Hutchinson
Targeted nanoparticles as immunostimulatory agents Dr Bala Ramesh Ivan P. Parkin
Temporal factors underlying thermal perception Patrick Haggard Andrew Macaskill
The economic and ecological value of social wasps: from food security to natural environments Seirian Sumner Beth Clare
The effect of hyperthermia on tissue permeality and viability in vitro and in vivo Dr M Thanou Nguyen Thanh
The effect of lipid composition on the mechanostransduction of individual live cells Sergi Garcia-Manyes Ulrike Eggert
The effect of nucleotide changes on the three-dimensional structure of immune receptor complexes Francesca Capon Franca Fraternali
The evolutionary genomics of accurate learning Robert Lachlan David Clayton
The genetic architecture of complex traits across diverse populations Karoline Kuchenbaecker Cathryn Lewis
The genetic basis of natural variation in complex innate behaviour Arantza Barrios Iasonas kokkinos
The genomic evolution of primate craniofacial anatomy Aida Gomez-Robles Aida Andres
The heart of the bacterial secretion machine Richard Pickersgill Vidya Darbari
The Human Brain: Leveraging omic data to discover the genetics of matching energy supply and demand in health and disease Mina Ryten Alan Hodgkinson
The human Nav1.1 sodium channel: Structure, Function, Drug Binding and Molecular Dynamics of Homologues Bearing Disease-Related Mutations Professor Bonnie Ann Wallace Dr. Martin Ulmschneider
The impact of cognition on the dynamics of emotions Prof. Raymond J Dolan, FRS Prof. Glyn Lewis
The impact of phage on the animal gut microbiome Joanne Santini Steven Van Winden
The importance of the microbiome in immune resistance to bacterial infection Rachel A. Lawrence Imelda M McGonnell
The maturation of the sensory-emotional pain network in the developing brain Maria Professor Sofia Olhede
The role of cAMP signalling in malaria parasite invasion of human red blood cells David Baker Mike Blackman
The role of chandelier cells in flexible behaviour Adil Khan Juan Burrone
The role of exosomes in regulating blood vessel calcification Isabel Orriss Chantal Chenu
The role of frontal-temporal cortices in relational knowledge and constructing models of the world Steve Kennerley Tim Behrens
The role of intracellular transport and protein aggregation during neuronal ageing. Alessio Vagnoni Chris Shaw
Towards alleviating the global crisis in antimicrobial resistance – developing a microfluidic device to screen for new biofilm-disrupting agents. Prof Asterios Gavriilidis Dr Elaine Allan
Towards an autonomous in silico researcher: Using abductive reasoning to automate the explanation of unexpected results Conrad Bessant Pedro Cutillas
Towards cell-free cell therapies Dr Gareth Williams Dr Rebecca Shipley
Towards understanding the neural mechanisms of mindful attention training for healthy ageing Eddy J. Davelaar Elena Antonova
Uncovering Interconnected Osteoarthritic Features: Using Directed Acyclic Graphs (DAGs) to Explore Relationships between Gait, Bone Shape and Joint Structure Yu-Mei Chang Andrew Pitsillides
Uncovering the antiviral activity of IFITM proteins using optical tweezers and light-sheet fluorescence microscopy Isabel Llorente-Garcia (ILLG) Mark Marsh (MM)
Understanding antibiotic biosynthesis towards the production of novel Anti-TB treatments Sarah Barry Dr. Maxie Roessler
Understanding appetite control through chemistry Dr. Lesley Ann Howell Dr. Peter J. McCormick
Understanding the association between infection acquisition and disease progression Katherine Atkins Stéphane Hué
Understanding the cell biological mechanisms underlying the broad-spectrum antiviral function of Interferon Induced Transmembrane (IFITM) proteins Camilla Benfield Mark Marsh
Understanding the emergent behaviour of cell motion Mark Miodownik Brian Stramer
Understanding the impact of a cholesterol-rich diet role on hepatic liver metabolism using mathematical models: focus on gender differences Vanessa Diaz Ines Pineda-Torra
Understanding the molecular basis for neurodegenerative disease Jeremy Carlton Adrian Isaacs
Understanding the relationships between extracellular matrix composition, structure, and mechanics in normal and scarred skin John Connelly Tanya Shaw
Understanding the subchondral bone remodelling in osteoarthritis progression in human joints: disease-relevant human tissue explant model Chaozong Liu Professor Andrew A Pitsillides
Unraveling the viral uracil-DNA glycosylase lytic replicative phase interaction hub in beta- and gamma- herpesviruses Maya Topf Renos Savva
Unscrambling the Egg: The Biochemistry and Cell Biology of Protein Aggregation Prof Daniel Raleigh Dr. Konstantinos Thalassinos
Updating head direction in a 3D world Kate Jeffery Neil Burgess
Using AI to determine DNA and RNA base modifications using 3rd generation sequencing technology Robert Lowe Dr Paul J. Hurd
Using Machine Learning to Anticipate Antimicrobial Resistance for Pathogen Surveillance and Therapeutic Stewardship Dr. Nicholas Furnham Prof. Taane Clark
Using methylation patterns in humans to identify genetic regions enabling rapid adaptation to environmental pressures. Matt Silver Garrett Hellenthal
Using whole genome sequencing to unravel the genetics underlying antimicrobial resistant pathogens Taane Clark Martin Hibberd
Viral transport through the nuclear pore complex and biomimetic pore complexes Bart Hoogenboom Ariberto Fassati
Walking and running with short legs and long: the scaling and ontogeny of the muscle mechanical compromise. James Usherwood Alan Wilson