Abstract
The ability of stem cells to regenerate damaged tissue has been widely demonstrated. Stem cells are often inherently immunogenic/tumorigenic however, and within a few days die and/or are cleared from the target site. There is mounting evidence that many bioactive compounds underpinning tissue regeneration are clustered in cell-secreted bodies known as extracellular vesicles (EVs). The application of EVs alone (without cells) can potentially be used in regenerative treatments, including for central nervous system pathologies. EVs display reduced immuno/tumorigenicity and growth of ectopic material, and permit more accurate dosing. In this project, we will develop advanced EV formulations for neural regeneration.
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