3D modelling and haemodynamic analysis of patient specific abdominal aortic aneurysms.

Richard Bomphrey (primary)
Comparative Biomedical Sciences
Royal Veterinary College
Yiannis Ventikos (secondary)
Mechanical Engineering


In an age of increased demand for cardiovascular interventions – surgical but also minimally invasive – there is an urgent need for improved and reliable prognostics in patients presenting with abdominal aortic aneurysms. Is it possible to inform predictions of rupture risk using biomedical imaging data direct from the clinic? This work builds on pre-existing simplified computational models that couple the fluid dynamics of blood with the structural dynamics of aortic tissue.


Khanafer, K. M., Bull, J. L. and Berguer, R. (2009) ‘Fluid-structure interaction of turbulent pulsatile flow within a flexible wall axisymmetric aortic aneurysm model’, European Journal of Mechanics, B/Fluids. Elsevier Masson SAS, 28(1), pp. 88–102. doi: 10.1016/j.euromechflu.2007.12.003.

Scotti, C. M. et al. (2005) ‘Fluid-structure interaction in abdominal aortic aneurysms: Effects of asymmetry and wall thickness’, BioMedical Engineering Online. doi: 10.1186/1475-925X-4-64.

Salsac, A.-V., Sparks, S. R. and Lasheras, J. C. (2004) ‘Hemodynamic changes occurring during the progressive enlargement of abdominal aortic aneurysms.’, Annals of vascular surgery. doi: 10.1007/s10016-003-0101-3.

Animal disease, health and welfareGenes, development and STEM* approaches to biology
Area of Biology
Techniques & Approaches
BiophysicsEngineeringImage ProcessingSimulation / Modelling