3D Printing Bioengineered Muscle

Dominic Wells (primary)
Comparative Biomedical Sciences
Royal Veterinary College
Richard Day (secondary)
Medicine
University College London

Abstract

Bioengineered muscle is emerging as a feasible regenerative medicine technology. This has been investigated most extensively in small sized pre-clinical models, with potential translation into humans being limited by constraints relating to scalability, cell alignment and tissue geometry. We aim to combinine existing knowledge of cell behaviour and traditional quantitative engineering approaches with new manufacturing technologies, notably 3D printing, to build human-scale constructs from a combination of living and synthetic materials that emulate behaviour of native muscle tissue. The project will generate new knowledge for translation into applications for regenerative medicine, drug screening, and in vitro tissue engineering models.


References

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BBSRC Area
Animal disease, health and welfare
Area of Biology
BiotechnologyCell Biology
Techniques & Approaches
BiochemistryBioinformaticsBiophysicsChemistryEngineeringImage ProcessingMicroscopy / ElectrophysiologyMolecular BiologySimulation / Modelling