Abstract
Whilst most of our understanding of the basic molecular principles of cancer have come from experimentation with single layer 2D cell culture models, they are not representative of the way cells interact in an in vivo environment. 3D cell cultures provide a much more realistic environment to simulate biological interactions and study invasiveness. Building on previous research this proposal will seek to develop novel optical imaging strategies which will enable for the first time, the complete interrogation of tumour derived 3D models, to understand how cancer cells are able to dissociate from the primary tumour and invade surrounding tissues.
References
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