A combined -omics approach to understanding pathogenicity and plant-resistance to Fusarium diseases of legume crops.

Andrew Armitage (primary)
Agriculture, Health and Environment Department
Natural Resources Institute (NRI), University of Greenwich
Laurence Bindschedler (secondary)
Department of Biological Sciences
Royal Holloway, University of London


Legumes play a vital role in food security, a major protein source in diet and improving soil health through nitrogen fixation. However, plant disease is a major limiting factor to yield across legume species. The fungal pathogen Fusarium oxysporum shows host adaptation across legume crops, possessing accessory chromosomes that confer pathogenicity to particular plant hosts. Genome sequencing across a range of legume pathogens will be used to identify origin and evolution of Fusarium pathogenicity chromosomes. Transcriptomic and proteomic approaches will be used to identify key fungal proteins involved in infection and the plant resistance proteins distinguishing resistant from susceptible cultivars.


Armitage, A.D.; Taylor, A; Sobczyk, M.K.; Baxter, L; Greenfield, B.P.J.; Bates, H.J.; Wilson, F.; Jackson, A.C.; Ott, S., Harrison, R.J.; Clarkson, J.P. (2018) Characterisation of pathogen-specific regions and novel effector candidates in Fusarium oxysporum f. sp. cepae. Scientific Reports, 8:13530. ISSN 2045-2322 (doi:https://doi.org/10.1038/s41598-018-30335-7)

Taylor, A.; Armitage, A.D.; Handy, C., Jackson, A.C.; Hulin, M.T.; Harrison, R.J.; Clarkson, J.P. (2019) Basal rot of Narcissus: Understanding pathogenicity in Fusarium oxysporum f. sp. narcissi. Frontiers in Microbiology, 10. ISSN 1664-302X (doi:https://doi.org/10.3389/fmicb.2019.02905)

Armitage, A.D.; Cockerton H.M.; Sreenivasaprasad, S.; Woodhall, J.; Lane, C.R., Harrison, R.J., Clarkson, J.P.; (2020) Genomics, Evolutionary History and Diagnostics of the Alternaria alternata Species Group Including Apple and Asian Pear Pathotypes; Front. Microbiol. 10, 3124. (doi:https://doi.org/10.3389/fmicb.2019.03124)

Lambertucci S.; Orman K.M.; Das Gupta S.; Fisher J.P.; Gazal S.; Williamson R.J.; Cramer R.; Bindschedler L.V. (2019) Analysis of barley leaf epidermis and extrahaustorial proteomes during powdery mildew infection reveals that the PR5 thaumatin-like protein TLP5 is required for susceptibility towards Blumeria graminis f.sp. hordei. Frontiers in Plant Sciences. (doi: 10.3389/fpls.2019.01138)

Stevenson, Philip C., Veitch, Nigel C. (1999) A 2-arylbenzofuran from roots of Cicer bijugum associated with fusarium wilt resistance. Phytochemistry, 48 (6). pp. 947-951. (doi:https://doi.org/10.1016/S0031-9422(97)00920-5)

Plants, microbes, food and sustainability
Area of Biology
Techniques & Approaches
BioinformaticsGeneticsMathematics / StatisticsMicroscopy / ElectrophysiologyMolecular Biology