A Gut Reaction: The role of the gut microbiome in zebrafish neuronal development

Imelda McGonnell (primary)
Comparative Biomedical Sciences
Royal Veterinary College
Anthony Graham (secondary)
Centre for Developmental Neurobiology
Kings College London


There is increasing evidence that bidirectional interactions between the microbiome and nerves play a normal physiological role in the adult nervous system. Evidence also suggest that perturbation of the microbiome may be involved in a wide variety of nervous system pathologies. The development of the nervous system and the maturation of the microbiome occur in parallel, however there are few studies that have examined the role of the microbiome in nervous system development. This project will use a germ free zebrafish model to investigate how the microbiome influences neuronal development and whether manipulation of microbiotal composition can ameliorate neurodevelopmental abnormalities.


1) Desbonnet et al., 2015 Brain Behav Immun. 48:165-73

2) Tognini 2017: Front Cell Neurosci.;11:25.

3) Rawls et al 2006: Cell 127:423-433

4) Chitnis et al 2012: Dev Neurobiol.;72:234–255.

Genes, development and STEM* approaches to biology
Area of Biology
Techniques & Approaches
Image ProcessingMicroscopy / ElectrophysiologyMolecular Biology