A multidisciplinary approach to elucidate the central mechanisms driving pain after bone fracture

Sandrine GERANTON (primary)
Cell and Developmental Biology
UCL
Chantal Chenu, Professor of Skeletal Biology (secondary)
Department of Comparative Biomedical Sciences
Royal Veterinary College

Abstract

Alleviating pain following bone fracture in both animals and humans is essential to allow the patient to participate in the physical rehabilitation necessary for full recovery. However, pain management after bone fracture is problematic and presents a growing problem, particularly among older individuals. This is because the mechanisms leading to bone pain after fracture are still not well understood. In this project, the PhD student will use a multidisciplinary approach to elucidate, in animals, the spinal mechanisms that maintain persistent pain after bone fracture using a range of behavioural, molecular and analytical approaches.


References

1. Srithunyarat, T. et al. Catestatin, vasostatin, cortisol, and pain assessments in dogs suffering from traumatic bone fractures. BMC Res. Notes 10, (2017).
2. Rollman, G. B. & Lautenbacher, S. Sex differences in musculoskeletal pain. Clin. J. Pain 17, 20–24 (2001).
3. Melton, L. J. Epidemiology of hip fractures: Implications of the exponential increase with age. Bone 18, S121–S125 (1996).
4. Woolf, C. J. Evidence for a central component of post-injury pain hypersensitivity. Nature 306, 686–688 (1983).
5. Maiarù, M. et al. The stress regulator FKBP51 drives chronic pain by modulating spinal glucocorticoid signaling. Sci. Transl. Med. 8, 325ra19 (2016).
6. Maiarù, M. et al. The Stress Regulator Fkbp51: A Novel and Promising Druggable Target for the Treatment of Persistent Pain States Across Sexes. PAIN 1 (2018). doi:10.1097/j.pain.0000000000001204


BBSRC Area
Animal disease, health and welfare
Area of Biology
Cell BiologyNeurobiology
Techniques & Approaches
BioinformaticsMathematics / StatisticsMicroscopy / ElectrophysiologyMolecular Biology