Abstract
This project will combine bioprinting, advanced imaging technologies and bioengineering techniques to complex scalable arrays of mini-tissues adapted for 3D imaging techniques. We will use 3D bioprinting to create complex patterns of cell populations on permeable polymer meshes, which will form the single layers of our mini-tissues, and characterise them using 3D imaging techniques. We will then be able assemble the single layers into complex 3D tissue-like constructs and image the interaction between the different cellular populations and patterns. This system will allow to study both cell-behaviour and cell responses to drugs within complex 3D multicellular constructs with defined architecture.
References
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