Accelerating the adoption of novel mosquito control interventions by combining entomological, epidemiological and genetic data using modelling

Oliver Brady (primary)
Infectious Disease Epidemiology
London School of Hygiene and Tropical Medicine
Sarah Hill (secondary)
Pathobiology and Population Sciences
Royal Veterinary College


Release of Wolbachia-infected mosquitoes is an early-stage novel intervention that aims to modify mosquito populations to eliminate arboviral diseases that affect over half the world’s population. Statistical and mathematical modelling techniques and phylogenetics can explain why effectiveness of interventions vary in different environments and predict where such interventions should be used.
We need to understand what factors currently limit Wolbachia implementation, predict what epidemiological impact coverage gaps will have and identify how coverage gaps could be filled with alternative mosquito control tools. Combined, this will assess how universally applicable Wolbachia will be and accelerate its development and implementation worldwide.


O’Reilly et al. BMC Med 17, 172 (2019).

Brady et al. BMC Med. 18, 186 (2020).

Yakob et al. PLoS Curr. 30, 9 (2017). 10.1371/currents.outbreaks.45deb8e03a438c4d088afb4fafae8747

Garcia et al. PLoS Negl Trop Dis 13(1): e0007023.

Ryan et al. Gates Open Research. 2019; 3: 1547. 10.12688/gatesopenres.13061.2

Genes, development and STEM* approaches to biology
Area of Biology
Techniques & Approaches
GeneticsMathematics / StatisticsSimulation / Modelling