Genome regulation is key to organisms’ capacity to buffer environmental fluctuations by expressing plastic changes to their phenotypes. Although fundamental to the genotype-phenotype map, many aspects of gene regulation and its evolution remain poorly understood. This project will fill some of these gaps. We will employ a tightly controlled experimental system in fission yeast Schizosaccharomyces pombe to study the dynamics of regulatory evolution. The research will allow us to better understand how adaptive trajectories of regulatory mechanisms depend on the interplay between selection pressures, mutational input and the topology of existing regulatory networks.
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