Abstract
Controlled destruction of the nucleus is required throughout the lifespan of an organism. Critical though this process is, little is known about the associated mechanisms as it is a difficult process to visualise except in epidermal keratinocytes, which undergo nuclear degradation as part of their terminal differentiation process. Using a combination of state-of-the-art live high resolution light microscopy, mass spectrometry and next generation RNA sequencing approaches, the PhD student will completely assess the nuclear degradation process in real time, defining the key events and landmarks of this process and their associated gene and protein expression changes.
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