Abstract
Understanding what cells do in embryonic development is an essential foundation to the application of novel stem cell-based regenerative therapies. Large image datasets are being generated in animal models of normal and dysmorphic embryonic development, but integrating these data is critical. Confocal imaging and cell property-mapping is being conducted in normal and birth defect-prone strains. This project is to integrate these multiple data modes, requiring spatial registration of images within and between specimens and generating maps of cell behaviours. Multimodal imaging approaches suitable for cell-scale analysis will be developed, using, and potentially informing, the latest medical imaging registration methods.
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