Biosensing viral vectors for enhancing manufacturing of gene therapy

Professor Farzin Farzaneh (primary)
Comprehensive Cancer Centre
King College London
Dr Wayne Dickson (secondary)
Photonics & Nanotechnology Group, Department of Physics
King's College London


Gene therapies including CAR-T cell immunotherapy have shown very promising results in clinical trials particularly haematological malignancies. Viral vector manufacture, used for producing CAR-T cells, represents a major bottleneck limiting the number of patients treated from individual cGMP vector batches. A major obstacle is the absence of a rapid and quantitative detection method for viral vectors that would enable accurate monitoring and feedback into the production process. This project aims to address this challenge by harnessing a unique type of optical biosensor based on a novel yet inexpensive optical metamaterial.


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Molecules, cells and industrial biotechnology
Area of Biology
BiotechnologyCell Biology
Techniques & Approaches
BiophysicsMolecular BiologySimulation / Modelling