Ca2+ and Viruses: Probing Novel Ca2+ Channels in Viral Entry.

Sandip Patel (primary)
Department of Cell and Developmental Biology
University College London
Mark Marsh (secondary)


The Ebola virus enters cells through late endosomes and has been shown recently to require a novel class of host Ca2+ channels known as the two-pore channels (TPCs) for infection. Our aim is to establish how human TPCs impact on virus entry and investigate whether TPCs might be targeted therapeutically to develop novel specific, or broad-spectrum, anti-virals. This project is of contemporary significance and offers broad training at the interface of cell signalling, membrane traffic, drug discovery and disease.


Marsh M, Helenius A. Virus entry: Open sesame. Cell 2006;124:729-740.

Patel, S. 2015. Function and dysfunction of two-pore channels. Sci. Signal. 8:re7.

Sakurada, Y., A.A.Kolokolstov, C.C.Chen, M.W.Tidwell, W.E.Bauta, N.Klugbauer, C.Grimm, C.Wahl-Schott, M.Biel, and R.A.Davey. 2015. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment. Science 347:6225.

Bekerman E, Einav S. Combating emerging viral threats. Science 2015;348:282-283.

Penny CJ, Vassileva K, Jha A, Yuan Y, Chee X, Yates E, Mazzon M, Kilpatrick BS, Muallem S, Marsh M, Rahman T, Patel S. Biochim Biophys Acta Mol Cell Res. 2019;1866:1151-1161.

Molecules, cells and industrial biotechnology
Area of Biology
Cell BiologyMicrobiology
Techniques & Approaches
BiochemistryGeneticsMicroscopy / ElectrophysiologyMolecular Biology