The Ebola virus enters cells through late endosomes and has been shown recently to require a novel class of host Ca2+ channels known as the two-pore channels (TPCs) for infection. Our aim is to establish how human TPCs impact on virus entry and investigate whether TPCs might be targeted therapeutically to develop novel specific, or broad-spectrum, anti-virals. This project is of contemporary significance and offers broad training at the interface of cell signalling, membrane traffic, drug discovery and disease.
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Penny CJ, Vassileva K, Jha A, Yuan Y, Chee X, Yates E, Mazzon M, Kilpatrick BS, Muallem S, Marsh M, Rahman T, Patel S. Biochim Biophys Acta Mol Cell Res. 2019;1866:1151-1161.