Cell migration is essential for morphogenesis, wound healing and immune response and plays a major role in cancer invasion during metastasis. By combining expertise in biomechanics (Charras) and in vivo cell migration (Mayor), we have uncovered a novel role for mechanics in regulating cell migration of neural crest cells, a highly motile embryonic cell type. This multi-disciplinary project will build on these findings to further investigate the role of tissue mechanics in cell migration in vivo. It does so through training in a number of molecular, cellular and biomechanical approaches applied both in vitro and in vivo, during embryo development.
1. Shellard A, Szabó A, Trepat X, Mayor R. Science. 2018 Oct 19;362(6412):339-343. doi: 10.1126/science.aau3301
2. Barriga EH, Franze K, Charras G, Mayor R. Nature. 2018 Feb 22;554(7693):523-527. doi: 10.1038/nature25742
3. Mayor, R., and S.Etienne-Manneville. 2016. The front and rear of collective cell migration. Nat. Rev. Mol. Cell Biol. 17:97-109
4. Moeendarbary E, L. Valon, Fritzsche M, Harris A, Moulding D, Thrasher A, Stride E, Mahadevan L, Charras G. “The cytoplasm behaves as a poroelastic material”, Nature Materials, 12(3):253-261, (2013).
5. Harris A, Peter L, Bellis J, Baum B, Kabla A, Charras G. “Characterising the mechanics of cell monolayers”, PNAS, 2012 Oct 9;109(41):16449-54.