Cell migration during embryo development requires interplay of physical and mechanical cues

Guillaume Charras (secondary)
Cell and Developmental Biology


Cell migration is essential for morphogenesis, wound healing and immune response and plays a major role in cancer invasion during metastasis. By combining expertise in biomechanics (Charras) and in vivo cell migration (Mayor), we have uncovered a novel role for mechanics in regulating cell migration of neural crest cells, a highly motile embryonic cell type. This multi-disciplinary project will build on these findings to further investigate the role of tissue mechanics in cell migration in vivo. It does so through training in a number of molecular, cellular and biomechanical approaches applied both in vitro and in vivo, during embryo development.


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3. Mayor, R., and S.Etienne-Manneville. 2016. The front and rear of collective cell migration. Nat. Rev. Mol. Cell Biol. 17:97-109

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Molecules, cells and industrial biotechnology
Area of Biology
Cell BiologyDevelopment
Techniques & Approaches
BioinformaticsBiophysicsImage ProcessingMathematics / StatisticsMicroscopy / ElectrophysiologyMolecular BiologySimulation / Modelling