Cellular plasticity and heterogeneous modes of migration in development, health and disease

Adrian Biddle (primary)
Centre for Cell Biology and Cutaneous Research, Blizard Institute
Queen Mary University of London
Victoria Sanz-Moreno (secondary)
Barts Cancer Institute
Queen Mary University of London

Abstract

Quantitative analysis of biological phenomena is key to advancing our understanding of their mechanistic underpinnings. Currently, the modes by which epithelial cells migrate in tissue development, regeneration and disease are only partially understood, mostly in qualitative terms. In this project, the student will develop a quantitative method for the analysis of cell migration in 3D under these different tissue states. A visit to our collaborating lab (Hannezo) at IST Austria will enable the student to learn biophysical modelling techniques that they can apply to their quantitative data to elucidate general rules governing cell migration in development, health and disease.


References

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BBSRC Area
Genes, development and STEM* approaches to biology
Area of Biology
Cell BiologyDevelopment
Techniques & Approaches
Image ProcessingMathematics / StatisticsMicroscopy / ElectrophysiologyMolecular BiologySimulation / Modelling