Abstract
The mammalian genome is arranged deliberately within the cell nucleus to promote communication between DNA elements and to compartmentalise specific functional activities. Chromosome conformation capture methods such as Hi-C and Capture Hi-C have begun to illuminate the scope and breadth of interactions, such as those between gene promoters and enhancers, providing unprecedented levels of information on gene regulation. However, it is surprising how many detectable interactions are poorly defined. This project aims to delve into the functional basis of unclassified genomic interactions to identify new forms of regulation and functional compartmentalisation of the genome.
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