Chromatin and epigenetic landscape of the human brain important for obesity

Radu Zabet (primary)
Blizard Institute
Queen Mary University of London
Dr Elena Bochukova (secondary)
Blizard Institute
Queen Mary University of London


Established very early in human development, body weight regulation is brain-governed by the hypothalamus. Consequently, hypothalamic dysfunction leads to obesity, and therefore understanding of gene regulatory logic in this brain area is of high importance. Cellular identity is provided by the set of genes that are active, which are controlled by the epigenetic landscape of the non-coding genome. Here, we plan to reconstruct the genome wide profiles of several architectural proteins and epigenetic marks in the hypothalamus. We will use then these datasets to identify and characterise the non-coding regulatory regions of the genome that control gene activity in hypothalamus.


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Beagan JA et al (2017) YY1 and CTCF orchestrate a 3D chromatin looping switch during neural lineage commitment Genome Res 27:1
Oh et al (2021) Enhancer release and retargeting activates disease-susceptibility genes Nature

Genes, development and STEM* approaches to biology
Area of Biology
Techniques & Approaches
BioinformaticsMathematics / StatisticsMolecular Biology