Abstract
Climate breakdown is acknowledged as the single greatest effect and challenge of the Anthropocene era. Its effect on human health and disease is predicted to be potentially overwhelming. Epilepsy is the most common serious chronic brain disease. The effect of climate breakdown on epilepsy has not been studied. Working with large-scale data from climate projections, downscaled to local regions, directly-recorded data on variation in seizures and comorbidities with current temperature patterns, and large-scale genomic data, the student will develop models for likely effects of climate breakdown on disease biology in epilepsy, laying foundations for targeted healthcare responses.
References
NHS responsibility in climate change:
https://www.hsj.co.uk/policy-and-regulation/stevens-nhs-must-take-more-responsibility-for-tackling-climate-change/7025155.article?mkt_tok=eyJpIjoiTUdVMlpXWTNNakV3TW1ObCIsInQiOiJFSjBZV3J6MkF5ZmZQdDJRNnhGakhVY0Q2YjBrNzExTWVORjEyNjQwbHdKcVJKdENZMGxZNmhYTVBRYjVoa2VNcG9aZ2lGRTBSSnRqUkFzQlRuanVlZVhYbDI1NFBuZzNBS01TNVBtNCtVNEpBRmV6QkxvMEhzZkdhZW9pSTQwWiJ9
Sisodiya SM, Scheffer IE, Lowenstein DH, Free SL. Why should a neurologist worry about climate change? Lancet Neurol. 2019 Apr;18(4):335-336.
Watts N, Amann M, Arnell N, et al. The 2018 report of the Lancet Countdown on health and climate change: shaping the health of nations for centuries to come. Lancet 2018 Dec 8; 392(10163):2479-2514.
Patz JA, Campbell-Lendrum D, Holloway T, et al. Impact of regional climate change on human health. Nature 2005 Nov 17;438(7066):310-7.
Parham PE, Waldock J, Christophides GK, et al. Climate, environmental and socio-economic change: weighing up the balance in vector-borne disease transmission. Philos Trans R Soc Lond B Biol Sci 2015;370(1665):20130551.
Samra JA, Hagood NL, Summer A, et al. Clinical Features and Neurologic Complications of Children Hospitalized with Chikungunya Virus in Honduras. J Child Neurol 2017 Jul;32(8):712-716.
Ramos R, Viana R, Brainer-Lima A et al. Perinatal Chikungunya Virus-associated Encephalitis Leading to Postnatal-Onset Microcephaly and Optic Atrophy. Pediatr Infect Dis J 2018 Jan;37(1):94-95.
Verma R, Varatharaj A et al. Epilepsia partialis continua as a manifestation of dengue encephalitis. Epilepsy Behav 2011 Feb;20(2):395-7.
Saad T, PennaeCosta AA, de Góes FV et al. Neurological manifestations of congenital Zika virus infection. Childs Nerv Syst 2018 Jan;34(1):73-78.
van der Linden H Jr, Carvalho MD, van der Linden V, et al. Epilepsy Profile in Infants with Congenital Zika Virus Infection. N Engl J Med 2018 Aug 30;379(9):891-892.
Campbell-Lendrum D, Manga L, Bagayoko M, et al. Climate change and vector-borne diseases: what are the implications for public health research and policy? Phil. Trans. R. Soc. B 2015 370:20130552.
Peters C, Rosch RE, Hughes E, et al. Temperature-dependent changes in neuronal dynamics in a patient with an SCN1A mutation and hyperthermia induced seizures. Sci Rep. 2016 Sep 1;6:31879.
Oguni H, Hayashi K, Awaya Y, et al. Severe myoclonic epilepsy in infants–a review based on the Tokyo Women’s Medical University series of 84 cases. Brain Dev 2001 Nov;23(7):736-48.
Verbeek NE, Wassenaar M, van Campen JS, et al. Seizure precipitants in Dravet syndrome: What events and activities are specifically provocative compared with other epilepsies? Epilepsy Behav. 2015 Jun;47:39-44.
de Kovel CG, Meisler MH, Brilstra EH, et al. Characterization of a de novo SCN8A mutation in a patient with epileptic encephalopathy. Epilepsy Res. 2014 Nov;108(9):1511-8.
Warner TA, Liu Z, Macdonald RL, et al. Heat induced temperature dysregulation and seizures in Dravet Syndrome/GEFS+ Gabrg2+/Q390X mice. Epilepsy Res. 2017 Aug;134:1-8.
Schubert J, Siekierska A, Langlois M, et al. Mutations in STX1B, encoding a presynaptic protein, cause fever-associated epilepsy syndromes. Nat Genet 2014 Dec;46(12):1327-32.