Abstract
Gamma oscillations have been implicated in information routing in the brain, but evidence of a causal link is lacking. The project builds on computational and experimental work that shows that closed-loop optogenetics can be used to modulate the frequency, phase and amplitude of gamma oscillations, without disrupting the average firing rate of principal neurons. Mice will be trained in a visual discrimination task, and the effects of manipulating gamma oscillations will be tested to determine whether perception and discrimination of visual stimuli can be biased by enhancing or suppressing spontaneous visually evoked gamma.
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