Combined molecular and physiological mapping of olfactory representation in the brain

Yoh Isogai (primary)
46 Cleveland Street
University College London
Andreas Schaefer (secondary)
Neuroscience, Physiology & Pharmacology
University College London/ Francis Crick Institute

Abstract

For many animals, olfaction is a critical sense. Animals acquire noxious and behaviorally important (food and social) information through scents, and smell often serves as a cue for specific memories. The logic of how smell, which typically consists of many odorants, forms a unique percept remains unclear. This project aims to map the molecular identities of the olfactory glomeruli, an elaborate structure that individual odorant inputs are relayed to the brain. In combination with in vivo calcium imaging of each glomerulus, we aim to create a map of the olfactory representation in the brain.


References

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BBSRC Area
Genes, development and STEM* approaches to biology
Area of Biology
NeurobiologyPhysiology
Techniques & Approaches
BioinformaticsImage ProcessingMathematics / StatisticsMicroscopy / ElectrophysiologyMolecular Biology