Abstract
Complex I is one of the most important components in the respiratory chain of mitochondria and is a major contributor of reactive oxygen species. As such, complex I dysfunction has been implicated in ageing and shown to account for as much as 1/3 of respiratory chain deficiencies. However, the mechanism of complex I is still poorly understood, so treatments are largely based on trial and error. This project combines biophysical, synthetic chemistry and computational techniques to elucidate the mechanism of the key energy-coupling step in complex I, which could underpin future medical studies and ultimately contribute to healthy ageing.
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