Acetylation of histone lysines is one of the most abundant modifications which alters chromatin structure and function. Gene mutations that perturb the histone acetylation pathway cause many neurodevelopmental disorders, warranting further investigation in understanding the specific role of the acetylation pathway in the central nervous system.
Focusing on reader proteins of histone acetylations, we aim to investigate the mechanism through which proteins involved in the acetylation pathway function in the development and regulation of the central nervous system. Overall, this proposal aims to decipher the epigenetic regulatory mechanism in neuronal development and function.
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