Design and development of novel bioinks for the development of in vitro tissue models for drug testing applications using 3D biofabrication process

Deepak kalaskar (primary)
UCL Division of surgery and Interventional Sciences
University College London
Dr Ryo Torii (secondary)
Department of Mechanical Engineering
University College London


The use of animal models for disease modeling and drug development are only current options to conduct preclinical studies. Animal models lack similarity and physiological complexity of human body. There is need to develop human specific in vitro tissue models which resemble complexity of human diseases and remain cost effective for large scale testing. This project aims to develop and characterise extracellular matrix analog of bioinks, which can be used for 3D biofabrication (bioprinting) process to fabricate composite tissues, which resembles human bone and cartilage tissues. This can later be used for disease modelling for osteoarthritis and thus relevant drug testing applications.


1. Popov, A. A., Malferrari, S., & Kalaskar, D. (2017). 3D Bioprinting for Musculoskeletal Applications. Journal of 3D Printing in Medicine, 1 (3), 191-211. doi:10.2217/3dp-2017-0004.

2. Das, A., BIswas, A., Maiti, S., & Kalaskar, D. M. (2018). Redox Active Dynamic Self-supporting Thixotropic 3D-printable G-quadruplex Hydrogel. Chemistry – An Asian Journal. doi:10.1002/asia.201801409.

3. Biswas, A., Malferrari, S., Kalaskar, D. M., & Das, A. K. (2018). Arylboronate esters mediated self-healable and biocompatible dynamic G-quadruplex hydrogels as promising 3D-bioinks. Chemical Communications. doi:10.1039/c7cc09051j.

4. Tenekecioglu E, Torii R, Bourantas CV, Al-Lamee R, Serruys PW (2017). Non-Newtonian pulsatile shear stress assessment: a method to differentiate bioresorbable scaffold platforms. European Heart Journal 38(33):2570.

5. Torii R, Velliou, R, Hodgson D, Mudera V. Modelling multi-scale cell-tissue interaction of tissue-engineered muscle constructs, Journal of Tissue Engineering, 9: 2041731418787141.

Animal disease, health and welfare
Area of Biology
BiotechnologyStructural Biology
Techniques & Approaches
BiochemistryChemistryEngineeringMathematics / StatisticsMicroscopy / ElectrophysiologyMolecular BiologySimulation / Modelling