Abstract
Intrinsically disordered proteins (IDPs) are associated with many disease states caused by parasites. Many key IDPs such as Small Hydrophilic Endoplasmic Reticulum-associated Protein (SHERP) from the parasite Leishmania major, adopt their active (folded) structure only when binding to their site of action in the host organism. The folded structure, though fleetingly in existence, is the potential target for the development both of antibodies and for rational drug design (RDD). The project aims are to generate a stable active SHERP structure for use as a template either for creating antibodies for potential vaccines, or for RDD of SHERP inhibitors in situ.
References
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