Intrinsically disordered proteins, such as Small Hydrophilic Endoplasmic Reticulum-associated Protein (SHERP) from Leishmania major, are becoming associated with many disease states. While not having a regular solution structure, an active structure only forms when binding to its key site of action. This structure is the perfect target for developing antibodies and for rational drug design, however, it exists for a fleeting period of time making it almost inaccessible as a target. The project aims are to generate a stable active structure form of SHERP capable of use as a template for creating antibodies and for rational drug design.
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