Wnt signaling is important during development and disease. We have discovered that Wnt signal activation is regulated by cell membrane electrical potential. The targets and mechanisms of action, part of this project, remain to be elucidated. Preliminary experiments show that nanoparticles (single walled carbon nano tubes, SWCNTs) may inhibit Wnt-signaling by acting on ion channels and/or Wnt receptors. We hypothesize that specifically designed SWCNTs act as membrane potential regulating compounds (MPRCs) to modulate the Wnt signaling activity. Development of SWCNTs as novel inhibitors for the Wnt pathway, using cutting edge biotechnology, will have wide application in basic and applied biology.
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