Curcumin is a natural anti-inflammatory and anti-oxidant compound with low water-solubility and bioavailability, no identified molecular targets, and pan essay interference which limits its clinical application. CNB-001, J-147 and T-006 are very potent synthetic curcumin derivatives with better characterized molecular targets, but also with low water-solubility. They dissolve in DMSO, which is toxic for humans. Nevertheless, they are trialed for neurodegeneration and stroke treatment. We aim to develop novel nanocarrier CNB-001, J-147 and T-006 formulations, thus overcoming DMSO-toxicity and water-solubility issues, re-formulating the derivatives for human intranasal use and testing their effect in neonatal hypoxia-ischaemia and adult facial axotomy models.
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Sisa C, Kholia SR, Naylor J, Herrera Sanchez MB, Bruno S, Deregibus MC, Camussi G, Inal JM, Lange S*, Hristova M*, Mesenchymal stromal cell derived extracellular vesicles reduce hypoxia-ischaemia induced perinatal brain injury, Front Physiol. 2019, https://doi.org/10.3389/fphys.2019.00282
Hristova M, Rocha-Ferreira E, Fontana X, Thei L, Buckle R, Christou M, Hompoonsup S, Gostelow N, Raivich G, Peebles D. Inhibition of Signal Transducer and Activator of Transcription 3 reduces neonatal hypoxic-ischemic brain damage. J Neurochem 2015, doi: 10.1111/jnc.13490
Deferoxamine and Curcumin Loaded Nanocarriers Protect Against Rotenone-Induced Neurotoxicity, Mursaleen L,Somavarapu S,Zariwala MG, J Parkinsons Dis 2020, http://dx.doi.org/10.3233/jpd-191754
Development and characterization of PLA nanoparticles for pulmonary drug delivery: Co-encapsulation of theophylline and budesonide, a hydrophilic and lipophilic drug, Buhecha MD, Lansley AB, Somavarapu S, Pannala AS, J Drug Deliv Sci Tec 2019, http://dx.doi.org/10.1016/j.jddst.2019.101128