Development and neuroprotective testing of nanocarrier formulations for intranasal administration of the curcumin derivatives CNB-001, J-147 and T-006

Mariya Hristova (primary)
Maternal and Fetal Medicine
EGA-Institute for Women’s Health, UCL
Satyanarayana Somavarapu (secondary)
UCL School of Pharmacy


Curcumin is a natural anti-inflammatory and anti-oxidant compound with low water-solubility and bioavailability, no identified molecular targets, and pan essay interference which limits its clinical application. CNB-001, J-147 and T-006 are very potent synthetic curcumin derivatives with better characterized molecular targets, but also with low water-solubility. They dissolve in DMSO, which is toxic for humans. Nevertheless, they are trialed for neurodegeneration and stroke treatment. We aim to develop novel nanocarrier CNB-001, J-147 and T-006 formulations, thus overcoming DMSO-toxicity and water-solubility issues, re-formulating the derivatives for human intranasal use and testing their effect in neonatal hypoxia-ischaemia and adult facial axotomy models.


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Deferoxamine and Curcumin Loaded Nanocarriers Protect Against Rotenone-Induced Neurotoxicity, Mursaleen L,Somavarapu S,Zariwala MG, J Parkinsons Dis 2020,

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Molecules, cells and industrial biotechnology
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BiotechnologyChemical Biology
Techniques & Approaches
BiophysicsChemistryImage ProcessingMathematics / StatisticsMicroscopy / ElectrophysiologyMolecular Biology