Neutrophil extracellular traps (NETs) play a key role in inflammatory disease processes associated with many central and peripheral diseases. Whilst effective in acute disease, excessive NETs formation can cause tissue damage and cause chronic inflammation, in particular through the activation of matrix metalloproteases (MMPs).
Taking advantage of hybrid imaging with positron emission tomography (PET) and magnetic resonance imaging (MRI) we aim to develop molecular imaging probes targeting both NETs and MMPs to understand the interplay between these two species in the inflammatory process.
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