The aim of this project is to dissect the changes in the host and viral genomes that enable adenoviral propagation. The project is based on evidence that major alterations in acetylation and methylation patterns of both host and viral genomes are essential for completion of the adenoviral life cycle. Using a combination of inhibitors of histone acetylases and deacetylases, siRNAs and RNAseq analysis the overall goal is to delineate the molecular pathways that are crucial for viral propagation.
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