Abstract
Changes in cell shape are required for several cellular processes, including cell migration and mitosis and they are induced by mechanical forces acting at the cell surface. Several proteins have been identified to be responsible for generating these forces. In this project we will investigate the role of a family of lipids in modulation of mechanical forces during cell migration and mitosis. To better characterise the interplay between molecular and mechanical clues we will also define whether changes in the biophysical/mechanical properties of substrates affect the levels and localisation of these lipids during migration and mitosis.
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