Does intensification of poultry production impact on Campylobacter evolution, microbiome variation and the risk of antimicrobial resistance?

Richard Stabler (primary)
Dept Infection Biology
LSHTM
Prof Damer Blake (secondary)
Pathobiology & Population Sciences
RVC

Abstract

The global burden of the foodborne disease Campylobacteriosis is substantial, with the greatest risks linked to chicken meat. Chicken is the most popular global source of animal protein, but intensification of production has relied on the overuse of antibiotics, creating conditions for generation and dissemination of antibiotic resistant bacteria threatening human health. We will work alongside the GCRF One Health Poultry Hub using Campylobacter isolates collected from four LMIC countries with complementary microbiome, metagenomics and antimicrobial residues data to investigate the effect of intensification on bacterial occurrence and evolution, the genetic drivers of virulence and the emergence of antimicrobial resistance.


References

1 Stabler, R.A.; Larsson, J.T.; Al-Jaberi, S.; Nielsen, E.M.; Kay, E.; Tam, C.C.; Higgins, C.D.; Rodrigues, L.C.; Richardson, J.F.; O’Brien, S.J.; Wren, B.W.; Characterization of water and wildlife strains as a subgroup of Campylobacter jejuni using DNA microarrays. Environ Microbiol (2013) 15(8):2371-83; DOI: 10.1111/1462-2920.12111; PMID: 23530835
2 Ugarte-Ruiz, M.; Stabler, R.A.; Domìnguez, L.; Porrero, M.C.; Wren, B.W.; Dorrell, N.; Gundogdu, O.; Prevalence of Type VI Secretion System in Spanish Campylobacter jejuni Isolates. Zoonoses Public Health (2015) 62(7):497-500; DOI: 10.1111/zph.12176; PMID: 25496466
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4 Hinsu AT, Thakkar JR, Koringa PG, Vrba V, Jakhesara SJ, Psifidi A, Guitian J, Tomley FM, Rank DN, Raman M, Joshi CG, Blake DP (2018) Illumina next generation sequencing for the analysis of Eimeria populations in commercial broilers and indigenous chickens. Frontiers in Veterinary Science. 5:176.
5 Pandit R, Hinsu AT, Patel NV, Koringa PG, Jakhesara SJ, Thakkar JR, Shah TM, Limon G, Psifidi A, Guitian J, Hume DA, Tomley FM, Rank DN, Raman M, Tirumurugaan KG, Blake DP, Joshi CG (2018) Microbial diversity and community composition of caecal microbiota in commercial and indigenous Indian chickens determined using 16s rDNA amplicon sequencing. Microbiome. 6:115.


BBSRC Area
Animal disease, health and welfare
Area of Biology
GeneticsMicrobiology
Techniques & Approaches
BioinformaticsGeneticsMolecular Biology