Dynamics of lipids and cerebral metabolism after injury and during recovery in the central nervous system

Adina T MICHAEL-TITUS (primary)
Centre for Neuroscience, Surgery and Trauma
Blizard Institute,Queen Mary University of London
Dr Jordi Lopez-Tremoleda (secondary)
Centre for Trauma Sciences
Blizard Institute,Queen Mary University of London


Lipids are major structural constituents of the central nervous system and are also involved in cell signalling. Injury of the nervous system induces changes in various lipid categories. How these changes evolve after injury and how they could be harnessed to promote restoration of brain networks is not understood. The project will characterize changes in structural lipids triggered by brain injury, image in parallel changes in blood flow, cerebral metabolism, neuroinflammation, and intervene with enzyme inhibitors and deuterated lipids to reduce injury impact – and thus lay a foundation for innovative approaches for lipid repair, supporting recovery.


Nessel I, Michael-Titus AT (2021) Lipid profiling of brain tissue and blood after traumatic brain injury. Seminars Cell. Dev Biol. 112, 145-156.
Huang W, Bhavsar A, Ward RE, Hall JCE, Priestley JV, Michael-Titus AT (2009) Arachidonyl trifluoro methyl ketone is neuroprotective after spinal cord injury. J Neurotrauma, 26, 12-16.
Sarkar C, Jones JW, Hegdekar N, Thayer JA, Kumar A, Faden AI, Kane MA, Lipinski MM (2020) PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma. Autophagy. 16, 466-485.
Raefsky SM, Furman R, Milne G, Pollock E, Axelsen P, Mattson MP, Shchepinov MS (2018) Deuterated fatty acids reduce brain lipid peroxidation and hippocampal amyloid beta peptide levels, without discernible behavioural effects in an APP/PS1 mutant transgenic mouse model of Alzheimer’s disease, Neurobiol Aging. 66, 165-176.
Tremoleda JL, Thau-Zuchman O, Davies M, Foster J, Khan I, Vadivelu KC, Yip PK, Sosabowski J, Trigg W, Michael-Titus AT (2016) In vivo PET imaging of the neuroinflammatory response in rat spinal cord injury using the TSPO tracer [18F[-GE180 and effect of docosahexaenoic acid. Eur J Nucl. Imaging. 43, 1710-1722.

Animal disease, health and welfare
Area of Biology
Techniques & Approaches
BiochemistryImage ProcessingMicroscopy / Electrophysiology