Lipids are major structural constituents of the central nervous system and are also involved in cell signalling. Injury of the nervous system induces changes in various lipid categories. How these changes evolve after injury and how they could be harnessed to promote restoration of brain networks is not understood. The project will characterize changes in structural lipids triggered by brain injury, image in parallel changes in blood flow, cerebral metabolism, neuroinflammation, and intervene with enzyme inhibitors and deuterated lipids to reduce injury impact – and thus lay a foundation for innovative approaches for lipid repair, supporting recovery.
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