Abstract
Hyperthermia has been identified as a method to treat tumors and to increase response to drug treatments. However, little is known on the effect of this combination on cancer stem cells. Our labs have developed hyperthermia protocols for disease treatments in combination with tailor made thermosensitive drug carriers and magnetic nanoparticles that interact with electromagnetic radiation to treat resistant tumours. Here, we propose to investigate the effects of electromagnetic radiation hyperthermia on mamosphere’s response to therapy, and understand the effects on function and proliferation, gene regulation and protein expression.
References
Centelles, MN, Wright, M, So, P-W, Amrahli, M, Xu, XY, Stebbing, J, Miller, AD, Gedroyc, W & Thanou, M 2018, ‘Image guided thermosensitive liposomes for focused ultrasound drug delivery: Using NIRF labelled lipids and topotecan to visualise the effects of hyperthermia in tumours’, JOURNAL OF CONTROLLED RELEASE. https://doi.org/10.1016/j.jconrel.2018.04.047
Thermosensitive, Near-Infrared-Labeled Nanoparticles for Topotecan Delivery to Tumors Rosca et al. 2015 Mol Pharm 12 (05)
MRI-Guided Focused Ultrasound as a New Method of Drug Delivery, Gedroyc and Thanou Journal of Drug Delivery (2013)
A. Hervault, M. Lim, C. Boyer, A. Dunn, D. Mott, S. Maenosono and N. T. K. Thanh (2016) Doxorubicin loaded dual pH- and thermo-responsive magnetic nanocarrier for combined magnetic hyperthermia and targeted controlled drug delivery applications. Nanoscale. DOI: 10.1039/c5nr07773g. Cover Page.
C. Blanco-Andujar, P. Southern, D. Ortega, S.A. Nesbitt, Q.A., Pankhurst and Thanh, N. T. K*. (2016) Real -time tracking of delayed-onset cellular apoptosis induce d by intracellular magnetic hyperthermia. Nanomedicine. 11: 121-136.