Abstract
Mutations in Leucine Rich Repeat Kinase 2 (LRRK2) are a common cause of Parkinson’s disease. We have previously shown that LRRK2 regulates canonical Wnt signalling in different tissues and affects bone architecture. Wnt signalling has also long been known to be important for bone homeostasis.
We will investigate the interplay of LRRK2 and Wnt signalling affecting tibial bone architecture in health and disease. The project will combe micro-computed tomography, primary cell culture and immunohistochemistry with imaging of bone and signalling pathways in live genetically modified animals providing key insights into LRRK2 mediated Wnt signalling on bone in health and disease.
References
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