Effect of viral coinfections on mastitis and breastmilk secretion

Theresa Ward (primary)
Department of Infection Biology
London School of Hygiene & Tropical Medicine
Suzanne Filteau (secondary)
DPH
LSHTM

Abstract

Milk production in humans and economically-important animals such as dairy cattle are very similar processes. Viral infections impact the nutritional content of breastmilk, can lead to offspring morbidity, and can cause mastitis both directly and indirectly. This has significant personal, societal and economic impact with both human breastfeeding and in dairy cows. We need to better understand viral secretion in breastmilk by investigating correlations in mastitis, viral loads (focusing on herpesviruses) and milk components. This will enable development of new interventions without compromising essential nutritional and immunological benefits of breastfeeding or dairy productivity.


References

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3 Wellenberg GJ, van der Poel WHM, Van Oirschot JT (2002) Viral infections and bovine mastitis: a review. Vet. Microbiol. 88:27-45

4 Slyker JA et al (2013) Clinical and virologic manifestations of primary Epstein-Barr virus infection in Kenyan infants born to HIV-infected women. J Infect Dis 207:1798-1806

5 Honvo-Hou├ęto E et al (2016) The endoplasmic reticulum and casein-containing vesicles contribute to the milk fat globule membrane. Mol Biol Cell 27:2946-64


BBSRC Area
Animal disease, health and welfare
Area of Biology
DevelopmentImmunology
Techniques & Approaches
BiochemistryBioinformaticsImage ProcessingMathematics / StatisticsMicroscopy / ElectrophysiologyMolecular Biology