Cells are continuously faced with stresses that can induce DNA damage. To maintain genomic integrity, cells have evolved the DNA damage response. Studies have identified a role for Drosophila Behaviour Human Splicing family members, NONO and SFPQ in DNA repair, however little is known about the role of PSPC1 in the DNA damage response. We have recently identified a role for PSPC1 in the response to DNA interstrand crosslinks (ICLs). However, it is unclear, at which specific step(s) in the response to ICL is PSPC1 acting. This studentship will determine the precise role for PSPC1 in the response to ICLs.
1 G. J. Knott, C. S. Bond, A. H. Fox, Nucleic Acids Res 44, 3989-4004 (2016).
2 H. W. Yeh et al., Nat Cell Biol 20, 479-491 (2018).
3 C. Rajesh, D. K. Baker, A. J. Pierce, D. L. Pittman, T, Nucleic Acids Res 39, 132-145 (2011).
4 A. Smogorzewska et al., Cell 129, 289-301 (2007).
5 I. Garcia-Higuera et al., Mol Cell 7, 249-262 (2001).