Engineered microenvironments forneuronal migration: Unveiling thefundamentals of neuronal locomotion andassociated migration disorders

Benedikt Berninger (primary)
Centre of Developmental Neurobiology
King's College London
Ciro Chiappini (secondary)
Centre for Craniofacial and Regenerative Biology
King's College London


A particular feature of brain development is the massive migration of immature neurons underlying the intricate connectivity that gives rise to complex brain sensorial and motor functions. The fact that more than 25 syndromes exist associated with neuronal migration disorders in humans highlights the vulnerability of this cellular process. However, lack of adequate models for studying migration has limited our understanding of the highly diverse nature of these developmental disorders. By combining expertise in developmental neurobiology (Berninger) and biomaterials (Chiappini) we aim at developing a platform for elucidating the migratory mechanisms of different neuronal types during development and in disease.


Berninger Lab
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Chiappini Lab
1. Onesto V, Barrell WB, Okesola M, et al. A quantitative approach for determining the role of geometrical constraints when shaping mesenchymal condensations. Biomed Microdevices.2019;21(2):44. Published 2019 Apr 8. doi:10.1007/s10544-019-0390-0
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3. Chiappini C, De Rosa E, Martinez JO, et al. Biodegradable silicon nanoneedles delivering nucleic acids intracellularly induce localized in vivo neovascularization. Nat Mater.2015;14(5):532-539. doi:10.1038/nmat4249

Genes, development and STEM* approaches to biology
Area of Biology
Cell BiologyDevelopmentGeneticsNeurobiology
Techniques & Approaches
BioinformaticsBiophysicsGeneticsImage ProcessingMathematics / StatisticsMicroscopy / ElectrophysiologyMolecular Biology