Abstract
A particular feature of brain development is the massive migration of immature neurons underlying the intricate connectivity that gives rise to complex brain sensorial and motor functions. The fact that more than 25 syndromes exist associated with neuronal migration disorders in humans highlights the vulnerability of this cellular process. However, lack of adequate models for studying migration has limited our understanding of the highly diverse nature of these developmental disorders. By combining expertise in developmental neurobiology (Berninger) and biomaterials (Chiappini) we aim at developing a platform for elucidating the migratory mechanisms of different neuronal types during development and in disease.
References
Berninger Lab
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Chiappini Lab
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