A particular feature of brain development is the massive migration of immature neurons underlying the intricate connectivity that gives rise to complex brain sensorial and motor functions. The fact that more than 25 syndromes exist associated with neuronal migration disorders in humans highlights the vulnerability of this cellular process. However, lack of adequate models for studying migration has limited our understanding of the highly diverse nature of these developmental disorders. By combining expertise in developmental neurobiology (Berninger) and biomaterials (Chiappini) we aim at developing a platform for elucidating the migratory mechanisms of different neuronal types during development and in disease.
1. Karow M, Camp JG, Falk S, et al. Direct pericyte-to-neuron reprogramming via unfolding of a neural stem cell-like program. Nat Neurosci. 2018;21(7):932-940. doi:10.1038/s41593-018-0168-3
2. Zhao S, Fan W, Guo X, et al. Microenvironments to study migration and somal translocation in cortical neurons. Biomaterials. 2018;156:238-247.doi:10.1016/j.biomaterials.2017.11.042
3. Ortega F, Gascón S, Masserdotti G, et al. Oligodendrogliogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibit differential responsiveness to Wnt signalling. Nat Cell Biol. 2013;15(6):602-613. doi:10.1038/ncb2736
1. Onesto V, Barrell WB, Okesola M, et al. A quantitative approach for determining the role of geometrical constraints when shaping mesenchymal condensations. Biomed Microdevices.2019;21(2):44. Published 2019 Apr 8. doi:10.1007/s10544-019-0390-0
2. Hansel CS, Crowder SW, Cooper S, et al. Nanoneedle-Mediated Stimulation of Cell Mechanotransduction Machinery. ACS Nano. 2019;13(3):2913-2926.doi:10.1021/acsnano.8b06998
3. Chiappini C, De Rosa E, Martinez JO, et al. Biodegradable silicon nanoneedles delivering nucleic acids intracellularly induce localized in vivo neovascularization. Nat Mater.2015;14(5):532-539. doi:10.1038/nmat4249