Abstract
Extracellular vesicles (EVs) play an important yet poorly understood role for intracellular communication. They are attracting growing interest as effective nanodelivery platforms that reduce toxicity and improve targeting. Yet, the limited ability to engineer their payload composition hampers the potential of EVs as cell-instructive elements for cell biology, tissue engineering and oncotherapy. Here we engineer the payloads of EVs by leveraging the upregulation of endocytosis induced by nanoneedles. Combining our expertise in drug delivery with that in the isolation, formulation and characterisation of EV we aim to develop a step-changing strategy to formulate nanoparticle-enriched EVs for delivery of biologicals.
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