Age related clonal haematopoiesis (ARCH) is a recently described entity where clonal populations of cells can be identified in blood. This occurs as part of the normal ageing process and affects 50% of individuals over the age of 80. These populations of cells are driven by mutations in epigenetic regulators and their presence confers an increase in mortality, mainly from stroke, cardiovascular disease and cancer. The purpose of this project is to model the evolution of ARCH using zebrafish to understand how such populations evolve over time, their effects on blood development and how this may disrupt normal haematopoietic homeostasis.
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