Abstract
Schistosomiasis is a neglected tropical disease which exerts a significant burden on humans and their animals, particularly the poorest people in sub-Saharan Africa. Praziquantel (PZQ) is the only available drug against schistosomiasis making the threat of resistance a particularly pertinent and worrying issue. By combining field sampling, diagnostic assays, molecular analysis and mathematical modelling, we aim to evaluate the likely impact of test-and-treat interventions on the population dynamics of livestock schistosomiasis. These findings will inform how best to control livestock schistosomiasis—while minimizing the risk of PZQ resistance developing—and how to prevent the further spread of hybrid schistosomes.
References
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