Evolutionary rewiring of cellular energy metabolism

Prof Snezhana Oliferenko (primary)
Randall Centre for Cell and Molecular Biophysics
King's College London (on secondment to the Francis Crick Institute)
Prof Jürg Bähler (secondary)
Research Department of Genetics, Evolution & Environment
University College London

Abstract

Energy metabolism is fundamental to all life. We want to understand how the regulation of energy metabolism evolves, and how it can be rewired to produce novel behaviors. This goal will be achieved by integrating bioinformatics, metabolomics and synthetic cell biology approaches in two related yeast species with different physiologies. Our work will provide critical insights into principles underlying metabolic changes associated with human aging and disease.


References

Makarova, M., Gu, Y., Chen, J-S., Beckley, J., Gould, K. and S. Oliferenko. 2016. Temporal regulation of Lipin activity diverged to account for differences in mitotic programs. Current Biology. 26:237-243.

Gu, Y., Yam, C. and S. Oliferenko. 2015. Rewiring of cellular division site selection in evolution of fission yeasts. Current Biology. 25:1187-1194.

Jeffares DC, Rallis C, Rieux A, Speed D, …., Bähler J. 2015. The genomic and phenotypic diversity of Schizosaccharomyces pombe. Nature Genetics. 47:235-241.

Malecki M, Bitton DA, Rodríguez-López M, Rallis C, Garcia Calavia N, Smith GC, Bähler J (2016). Functional and regulatory profiling of energy metabolism in fission yeast. Genome Biology 17:240

Rodríguez-López M, Cotobal C, Fernández-Sánchez O, Borbarán Bravo N, Oktriani R, Abendroth H, Uka D, Hoti M, Wang J, Zaratiegui M, Bähler J (2017). A CRISPR/Cas9-based method and primer design tool for seamless genome editing in fission yeast. Wellcome Open Research 1:19


BBSRC Area
Plants, microbes, food and sustainability
Area of Biology
BiotechnologyEvolution
Techniques & Approaches
BiochemistryBioinformaticsBiophysicsEngineeringGeneticsImage ProcessingMathematics / StatisticsMicroscopy / ElectrophysiologyMolecular Biology