Finite-element modelling of the inner ear and experimental characterization of its mechanical properties

Torsten Marquardt (primary)
Ear Institute
UCL
Núria Gavara (secondary)
QMUL
Institute of Bioengineering

Abstract

After almost a century of modern research, the details of the mechanical excitation of the inner ear remain controversial (e.g. [1]). The main reason is the inaccessibility of this intricate biomechanical apparatus to obtain in-vivo experimental data from fully sensitive specimen. Computational modelling has therefore been historically an integral part of this research field (reviewed in [2]). Recent technological developments allow the reliable mechanical characterization of the micro-scale structures within the hearing organ (e.g. [3]). The project will combine finite-element modelling (e.g. [4], [5]) of the cochlear vibrations with experimental measurements of missing parameter values from fresh cochlear tissue.


References

Van der Heijden M, Versteegh CPC. Energy Flux in the Cochlea: Evidence Against Power Amplification of the Traveling Wave. JARO: Journal of the Association for Research in Otolaryngology. 2015;16(5):581-597. doi:10.1007/s10162-015-0529-5.
Lighthill J. Energy flow in the cochlea. J Fluid Mech. 1981;106:149–213. doi: 10.1017/S0022112081001560.
Gavara N, Chadwick RS (2009) Collagen-Based Mechanical Anisotropy of the Tectorial Membrane: Implications for Inter-Row Coupling of Outer Hair Cell Bundles. PLoS ONE 4(3): e4877. doi:10.1371/journal.pone.0004877
Liu, Y., Gracewski, S. M. & Nam, J. H. (2015) Consequences of location-dependent
organ of corti micro-mechanics. PLoS ONE 10, e0133284
Ni, G., Elliott, J., & Baumgart, J. (2016). Finite-element model of the active organ of Corti., 13(115). do: 10.1098/rsif.2015.0913


BBSRC Area
Animal disease, health and welfare
Area of Biology
PhysiologyStructural Biology
Techniques & Approaches
EngineeringMicroscopy / ElectrophysiologySimulation / Modelling