The malaria parasite protein PF14_0604, which is produced in the stage of the parasite lifecycle that is transferred to the mosquito, is a putative phospholipid-transfer protein that may be very important for the transmission of the parasite to the mosquito. This project will investigate phospholipid transfer of PF14_0604 through biochemical assays and the function of the protein through genetic modification of the parasite. The function of the protein will be further investigated through determination of the structure of the protein through crystallography, which will additionally provide insight into the expansion and divergence of the protein family in rodent malaria parasites.
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