The Fam-a family of phospholipid transfer proteins is present in all malaria parasites. Interestingly, this family has expanded greatly in rodent malaria parasites. Despite its conservation, the role of this protein family remains entirely unknown, although its conservation points to an important function in parasite survival and pathogenesis. This project will investigate the biochemical and cellular function of this family through in vitro assays and genetic modification of the parasite, followed by phenotypic analysis in culture and during mosquito infections. Function and divergence of the members of the family will be further investigated by determination of protein structures through crystallography.
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2. Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes: molecular insight into sex-specific processes and translational repression. Lasonder E, Rijpma SR, van Schaijk BC, Hoeijmakers WA, Kensche PR, Gresnigt MS, Italiaander A, Vos MW, Woestenenk R, Bousema T, Mair GR, Khan SM, Janse CJ, Bártfai R, Sauerwein RW. Nucleic Acids Res. 44:6087-101, 2016
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