Abstract
In humans, disorders that affect neuron and glia development are associated with remarkable genetic heterogeneity. Using the fruit fly as a model combined with in vivo imaging and in silico mathematical modelling, we will study how specific genetic changes impact on clonal development, growth and behaviour of glial cell populations. For this, we will develop a novel genetic system that will allow the study of clonal interactions and their effect on clonal growth. This project will further our knowledge of how clonal heterogeneity can influence growth, which will elucidate the impact of genetic heterogeneity on brain development.
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