Abstract
Pancreatic beta cell disease in dogs can manifest as diabetes mellitus, where beta cells are destroyed, or insulinoma, where these cells undergo malignant transformation. Samoyed dogs are highly susceptible to the former, suggesting that they have ‘fragile’ beta cells. In contrast, Boxer dogs rarely develop diabetes, but are prone to developing insulinomas. The aim of this project is to identify novel genes involved in pancreatic beta cell function, apoptosis and regeneration, by whole genome sequencing analysis in Boxers and Samoyeds. It is anticipated that this will provide insight into pathways and molecular targets that might be suitable for therapeutic intervention.
References
- Holder AL, Kennedy LJ, Ollier WE, Catchpole B. Breed differences in development of anti-insulin antibodies in diabetic dogs and investigation of the role of dog leukocyte antigen (DLA) genes. Vet Immunol Immunopathol. 2015 Oct 15;167(3-4):130-8.
- Short AD, Holder A, Rothwell S, Massey J, Scholey R, Kennedy LJ, Catchpole B, Ollier WE. Searching for “monogenic diabetes” in dogs using a candidate gene approach. Canine Genet Epidemiol. 2014 Jul 7;1:8.
- Catchpole B, Adams JP, Holder AL, Short AD, Ollier WE, Kennedy LJ. Genetics of canine diabetes mellitus: are the diabetes susceptibility genes identified in humans involved in breed susceptibility to diabetes mellitus in dogs? Vet J. 2013 Feb;195(2):139-47.
- Catchpole B, Kennedy LJ, Davison LJ, Ollier WE. Canine diabetes mellitus: from phenotype to genotype. J Small Anim Pract. 2008 Jan;49(1):4-10
- Goutal CM, Brugmann BL, Ryan KA. Insulinoma in dogs: a review. J Am Anim Hosp Assoc. 2012 May-Jun;48(3):151-63