Geospatial modeling of an ongoing Salmonella typhi outbreak in Harare Zimbabwe in the context of mass vaccination campaign

Dr Steven Le Comber (primary)
School of Biological and Chemical Sciences
Queen Mary University of London
Dr Katharina Kranzer (secondary)
Clinical Research Department, Faculty of Infectious Disease and Tropical Medicine
London School of Hygiene & Tropical Medicine


This project will investigate an ongoing typhoid outbreak in Harare, Zimbabwe using geographic profiling and classic epidemiology. Whole genome sequencing data from Salmonella typhi outbreak isolates will be investigated using bioinformatics methods. Data for this project will be collected as part of an ongoing multi-country study investigating the causes of fever.


– Verity R, Stevenson MD, Rossmo DK, Nichols RA & Le Comber SC. 2014. Spatial targeting of infectious disease control: identifying multiple, unknown sources. Methods in Ecology and Evolution, 5, 647-655.
– Notes from the Field: Typhoid Fever Outbreak – Harare, Zimbabwe, October 2017-February 2018. N’cho HS, Masunda KPE, Mukeredzi I, Manangazira P, Govore E, Duri C, Aubert RD, Martin H, Gonese E, Vere M, Tippett Barr BA, Balachandra S, Strysko J, Davis WW, Appiah GD, Mintz E. MMWR Morb Mortal Wkly Rep. 2019 Jan 18;68(2):44-45.
– Le Comber SC, Rossmo DK, Hassan AN, Fuller DO & Beier JC. 2011. Geographic profiling as a novel spatial tool for targeting infectious disease control. International Journal of Health Geographics 10, 35.

Animal disease, health and welfare
Area of Biology
Techniques & Approaches
BioinformaticsMathematics / StatisticsSimulation / Modelling