Healthy ageing: The role of biomolecular charge

Patrick Mesquida (primary)
Experimental Biophysics and Nanotechnology Group Department of Physics
King's College London
Andela Saric (secondary)
Institute for the Physics of Living Systems Department of Physics & Astronomy
University College London

Abstract

Experimental scanning-probe methods in combination with computer simulations will be used to investigate the charge of biomolecules and how this affects their assembly into fibrils and tissues. The particular focus will be on the influence of glycation on charge, which is thought to be one of the key contributors to the negative effects of human ageing.


References

  1. Molecular Basis of Arterial Stiffening: Role of Glycation – A Mini-Review, D.R. Sell, V.M. Monnier, Gerontology, 58 (2012) 227
  2. Kelvin-probe force microscopy of the pH-dependent charge of functional groups, ADD Stone, P Mesquida, Applied Physics Letters 2016, 108 (23), 233702
  3. Physical determinants of the self-replication of protein fibrils, A Saric et al, Nature Physics 2016, 12, 874.

BBSRC Area
Molecules, cells and industrial biotechnology
Area of Biology
Chemical BiologyStructural Biology
Techniques & Approaches
BioinformaticsBiophysicsMicroscopy / ElectrophysiologySimulation / Modelling